ParkinsonCanadaV1, Main, Exploration, bibRecord, 001634

Modeling Neurodegeneration in Zebrafish

Identifieur interne : 001634 ( Main/Exploration ); précédent : 001633; suivant : 001635

Modeling Neurodegeneration in Zebrafish

Auteurs : Yanwei Xi ; Sandra Noble ; Marc Ekker

Source :

Current Neurology and Neuroscience Reports [ 1528-4042 ] ; 2011.

RBID : PMC:3075402

English descriptors

KwdEn :
- Alzheimer Disease (genetics), Animals, Disease Models, Animal, Humans, Huntington Disease (genetics), Intracellular Signaling Peptides and Proteins (genetics), LDL-Receptor Related Proteins (genetics), Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Membrane Transport Proteins (genetics), Neurodegenerative Diseases (genetics), Neurodegenerative Diseases (pathology), Neurodegenerative Diseases (physiopathology), Oncogene Proteins (genetics), Parkinson Disease (genetics), Protein Deglycase DJ-1, Protein Kinases (genetics), Protein-Serine-Threonine Kinases (genetics), Ubiquitin-Protein Ligases (genetics), Zebrafish (genetics), tau Proteins (genetics).
MESH :
- chemical , genetics : Intracellular Signaling Peptides and Proteins, LDL-Receptor Related Proteins, Membrane Transport Proteins, Oncogene Proteins, Protein Kinases, Protein-Serine-Threonine Kinases, Ubiquitin-Protein Ligases, tau Proteins.
- genetics : Alzheimer Disease, Huntington Disease, Neurodegenerative Diseases, Parkinson Disease, Zebrafish.
- pathology : Neurodegenerative Diseases.
- physiopathology : Neurodegenerative Diseases.
- Animals, Disease Models, Animal, Humans, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Protein Deglycase DJ-1.

Abstract

The zebrafish, Danio rerio, has been established as an excellent vertebrate model for the study of developmental biology and gene function. It also has proven to be a valuable model to study human diseases. Here, we reviewed recent publications using zebrafish to study the pathology of human neurodegenerative diseases including Parkinson’s, Huntington’s, and Alzheimer’s. These studies indicate that zebrafish genes and their human homologues have conserved functions with respect to the etiology of neurodegenerative diseases. The characteristics of the zebrafish and the experimental approaches to which it is amenable make this species a useful complement to other animal models for the study of pathologic mechanisms of neurodegenerative diseases and for the screening of compounds with therapeutic potential.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075402

DOI: 10.1007/s11910-011-0182-2
PubMed: 21271309
PubMed Central: 3075402

Affiliations:

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<front><div type="abstract" xml:lang="en"><p>The zebrafish, <italic>Danio rerio</italic>
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La maladie de Parkinson au Canada (serveur d'exploration)

Modeling Neurodegeneration in Zebrafish

Modeling Neurodegeneration in Zebrafish

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
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